Gluten-sensitive enteropathy

Gluten-sensitive enteropathy: Synthesis

The intestinal mucosa of patients with gluten-sensitive enteropathy responds to gluten challenge in vivo with a striking increase in IgA and IgM synthesis. Whether this increase in immunoglobulin synthesis is due in some part to the production of antigliadin antibodies is examined. Using an affinity chromatography technique it has been demonstrated that in six of seven patients with gluten-sens...

Gluten-sensitive enteropathy (celiac disease): more common than you think.

Gluten-sensitive enteropathy or, as it is more commonly called, celiac disease, is an autoimmune inflammatory disease of the small intestine that is precipitated by the ingestion of gluten, a component of wheat protein, in genetically susceptible persons. Exclusion of dietary gluten results in healing of the mucosa, resolution of the malabsorptive state, and reversal of most, if not all, effect...

Gluten-sensitive enteropathy associated with genital lichen simplex chronicus

A 49-year-old woman presented to the dermatology department with a 10-year history of anogenital itching. The pruritus was often so severe that she would scratch until she drew blood. Her symptoms had been partially controlled with Dermovate NN cream during the year prior to her presentation but were still impacting heavily on her quality of life. She denied the use of wet wipes, soap or pant l...

Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration.

The broad spectrum of celiac disease and gluten sensitive enteropathy

The celiac disease is an immune chronic condition with genetic transmission, caused by the intolerance to gluten. Gluten is a protein from cereals containing the following soluble proteins: gliadine, which is the most toxic, and the prolamins. The average prevalence is about 1% in USA and Europe, but high in Africa: 5.6% in West Sahara. In the pathogenesis several factors are involved: gluten a...